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The Apparent Requirement for Protein Synthesis during G2 Phase Is due to Checkpoint Activation
Protein synthesis inhibitors (e.g., cycloheximide) block mitotic entry, suggesting that cell cycle progression requires protein synthesis until right before mitosis. However, cycloheximide is also known to activate p38 mitogen-activated protein kinase (MAPK), which can delay mitotic entry through a...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802425/ https://www.ncbi.nlm.nih.gov/pubmed/32668239 http://dx.doi.org/10.1016/j.celrep.2020.107901 |