The CH1α domain of mucosal gp41 IgA contributes to antibody specificity and antiviral functions in HIV-1 highly exposed Sero-Negative individuals

The antibody molecule comprises a variable domain conferring antigen specificity and affinity distinct from the heavy chain constant (CH) domains dictating effector functions. We here interrogate this paradigm by evaluating the unique influence of the CH1α domain on epitope specificity and functions...

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Detalles Bibliográficos
Autores principales: Khamassi, Marwa, Xu, Lin, Rey, Julien, Duchemin, Maxence, Bouceba, Tahar, Tuffery, Pierre, Tudor, Daniela, Bomsel, Morgane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802955/
https://www.ncbi.nlm.nih.gov/pubmed/33315937
http://dx.doi.org/10.1371/journal.ppat.1009103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802955/
https://www.ncbi.nlm.nih.gov/pubmed/33315937
http://dx.doi.org/10.1371/journal.ppat.1009103

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