Factual insights of the allosteric inhibition mechanism of SARS-CoV-2 main protease by quercetin: an in silico analysis

SARS-CoV-2 main protease (M(pro)) cleaves the viral polypeptide 1a and 1ab in a site-specific ((L-Q|(S, A, G)) manner and produce functional enzymes for mediating viral replication. Numerous studies have reported synthetic competitive inhibitors against this target enzyme but increase in substrate c...

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Detalles Bibliográficos
Autores principales: Verma, Shalja, Pandey, Anand Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802979/
https://www.ncbi.nlm.nih.gov/pubmed/33457176
http://dx.doi.org/10.1007/s13205-020-02630-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802979/
https://www.ncbi.nlm.nih.gov/pubmed/33457176
http://dx.doi.org/10.1007/s13205-020-02630-6

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