A dual inhibitor targeting HMG-CoA reductase and histone deacetylase mitigates neurite degeneration in LRRK2-G2019S parkinsonism

Parkinson’s disease (PD) is among the most common neurodegenerative disorders, and its etiology involves both genetic and environmental factors. The leucine-rich repeat kinase (LRRK2) G2019S mutation is the most common genetic cause of familial and sporadic PD. Current treatment is limited to dopami...

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Detalles Bibliográficos
Autores principales: Lin, Chin-Hsien, Lin, Han-Yi, Fang, Jim-Min, Chen, Ching-Chow
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803522/
https://www.ncbi.nlm.nih.gov/pubmed/33231564
http://dx.doi.org/10.18632/aging.104165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803522/
https://www.ncbi.nlm.nih.gov/pubmed/33231564
http://dx.doi.org/10.18632/aging.104165

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