Age-associated deficient recruitment of 53BP1 in G1 cells directs DNA double-strand break repair to BRCA1/CtIP-mediated DNA-end resection

DNA repair mechanisms play a crucial role in maintaining genome integrity. However, the increased frequency of DNA double-strand breaks (DSBs) and genome rearrangements in aged individuals suggests an age-associated DNA repair deficiency. Previous work from our group revealed a delayed firing of the...

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Detalles Bibliográficos
Autores principales: Anglada, Teresa, Genescà, Anna, Martín, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803562/
https://www.ncbi.nlm.nih.gov/pubmed/33361520
http://dx.doi.org/10.18632/aging.202419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803562/
https://www.ncbi.nlm.nih.gov/pubmed/33361520
http://dx.doi.org/10.18632/aging.202419

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