Base-modified aptamers obtained by cell-internalization SELEX facilitate cellular uptake of an antisense oligonucleotide

Intracellular delivery of oligonucleotides is important for their use as therapeutic drugs. The conjugation of molecules interacting with cell membrane proteins to enhance their internalization into cells is an effective strategy for delivering oligonucleotides. In the present study, we focused on c...

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Detalles Bibliográficos
Autores principales: Tanaka, Keisuke, Okuda, Takumi, Kasahara, Yuuya, Obika, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803630/
https://www.ncbi.nlm.nih.gov/pubmed/33473329
http://dx.doi.org/10.1016/j.omtn.2020.11.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803630/
https://www.ncbi.nlm.nih.gov/pubmed/33473329
http://dx.doi.org/10.1016/j.omtn.2020.11.016

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