Collective synthesis of acetylenic pharmaceuticals via enantioselective Nickel/Lewis acid-catalyzed propargylic alkylation

Chiral acetylenic derivatives are found in many bioactive compounds and are versatile functional groups in organic chemistry. Here, we describe an enantioselective nickel/Lewis acid-catalyzed asymmetric propargylic substitution reaction from simple achiral materials under mild condition. The introdu...

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Detalles Bibliográficos
Autores principales: Chang, Xihao, Zhang, Jiayin, Peng, Lingzi, Guo, Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803749/
https://www.ncbi.nlm.nih.gov/pubmed/33436637
http://dx.doi.org/10.1038/s41467-020-20644-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803749/
https://www.ncbi.nlm.nih.gov/pubmed/33436637
http://dx.doi.org/10.1038/s41467-020-20644-9

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