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DHA/AA alleviates LPS-induced Kupffer cells pyroptosis via GPR120 interaction with NLRP3 to inhibit inflammasome complexes assembly

Pyroptosis is a novel type of programmed cell death associated with the pathogenesis of many inflammatory diseases. Docosahexaenoic acid (DHA) and Arachidonic acid (AA) is widely involved in inflammatory pathological processes. However, the effect and mechanism of DHA and AA on pyroptosis in Kupffer...

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Detalles Bibliográficos
Autores principales: Fan, Guoqiang, Li, Yanfei, Chen, Jinglong, Zong, Yibo, Yang, Xiaojing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803970/
https://www.ncbi.nlm.nih.gov/pubmed/33436541
http://dx.doi.org/10.1038/s41419-020-03347-3