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Establishment of a long-term stable β-cell line and its application to analyze the effect of Gcg expression on insulin secretion

A pancreatic β-cell line MIN6 was previously established in our lab from an insulinoma developed in an IT6 transgenic mouse expressing the SV40 T antigen in β-cells. This cell line has been widely used for in vitro analysis of β-cell function, but tends to lose the mature β-cell features, including...

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Detalles Bibliográficos
Autores principales: Miyazaki, Satsuki, Tashiro, Fumi, Tsuchiya, Takashi, Sasaki, Kazuki, Miyazaki, Jun-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804151/
https://www.ncbi.nlm.nih.gov/pubmed/33436850
http://dx.doi.org/10.1038/s41598-020-79992-7