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Establishment of a long-term stable β-cell line and its application to analyze the effect of Gcg expression on insulin secretion
A pancreatic β-cell line MIN6 was previously established in our lab from an insulinoma developed in an IT6 transgenic mouse expressing the SV40 T antigen in β-cells. This cell line has been widely used for in vitro analysis of β-cell function, but tends to lose the mature β-cell features, including...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804151/ https://www.ncbi.nlm.nih.gov/pubmed/33436850 http://dx.doi.org/10.1038/s41598-020-79992-7 |