Structural basis for the multi-activity factor Rad5 in replication stress tolerance

The yeast protein Rad5 and its orthologs in other eukaryotes promote replication stress tolerance and cell survival using their multiple activities, including ubiquitin ligase, replication fork remodeling and DNA lesion targeting activities. Here, we present the crystal structure of a nearly full-le...

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Detalles Bibliográficos
Autores principales: Shen, Miaomiao, Dhingra, Nalini, Wang, Quan, Cheng, Chen, Zhu, Songbiao, Tian, Xiaolin, Yu, Jun, Gong, Xiaoxin, Li, Xuzhichao, Zhang, Hongwei, Xu, Xin, Zhai, Liting, Xie, Min, Gao, Ying, Deng, Haiteng, He, Yongning, Niu, Hengyao, Zhao, Xiaolan, Xiang, Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804152/
https://www.ncbi.nlm.nih.gov/pubmed/33436623
http://dx.doi.org/10.1038/s41467-020-20538-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804152/
https://www.ncbi.nlm.nih.gov/pubmed/33436623
http://dx.doi.org/10.1038/s41467-020-20538-w

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