Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice

Patients with chronic kidney disease (CKD) have elevated circulating levels of trimethylamine N-oxide (TMAO), a metabolite derived from gut microbes and associated with cardiovascular diseases. High circulating levels of TMAO and its dietary precursor, choline, predict increased risk for development...

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Detalles Bibliográficos
Autores principales: Zhang, Wenchao, Miikeda, Aika, Zuckerman, Jonathan, Jia, Xun, Charugundla, Sarada, Zhou, Zhiqiang, Kaczor-Urbanowicz, Karolina Elżbieta, Magyar, Clara, Guo, Fangfei, Wang, Zeneng, Pellegrini, Matteo, Hazen, Stanley L., Nicholas, Susanne B., Lusis, Aldons J., Shih, Diana M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804188/
https://www.ncbi.nlm.nih.gov/pubmed/33436815
http://dx.doi.org/10.1038/s41598-020-80063-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804188/
https://www.ncbi.nlm.nih.gov/pubmed/33436815
http://dx.doi.org/10.1038/s41598-020-80063-0

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