Sterol auto-oxidation adversely affects human motor neuron viability and is a neuropathological feature of amyotrophic lateral sclerosis

Aberrant cholesterol homeostasis is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), a fatal neuromuscular disease that is due to motor neuron (MN) death. Cellular toxicity from excess cholesterol is averted when it is enzymatically oxidized to oxysterols and bile acids (BAs) t...

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Detalles Bibliográficos
Autores principales: Dodge, James C., Yu, Jinlong, Sardi, S. Pablo, Shihabuddin, Lamya S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804278/
https://www.ncbi.nlm.nih.gov/pubmed/33436868
http://dx.doi.org/10.1038/s41598-020-80378-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804278/
https://www.ncbi.nlm.nih.gov/pubmed/33436868
http://dx.doi.org/10.1038/s41598-020-80378-y

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