Cargando…

Sterol auto-oxidation adversely affects human motor neuron viability and is a neuropathological feature of amyotrophic lateral sclerosis

Aberrant cholesterol homeostasis is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), a fatal neuromuscular disease that is due to motor neuron (MN) death. Cellular toxicity from excess cholesterol is averted when it is enzymatically oxidized to oxysterols and bile acids (BAs) t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dodge, James C., Yu, Jinlong, Sardi, S. Pablo, Shihabuddin, Lamya S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804278/ https://www.ncbi.nlm.nih.gov/pubmed/33436868 http://dx.doi.org/10.1038/s41598-020-80378-y

Ejemplares similares

Glucosylceramide synthase inhibition reduces ganglioside GM3 accumulation, alleviates amyloid neuropathology, and stabilizes remote contextual memory in a mouse model of Alzheimer’s disease
por: Dodge, James C., et al.
Publicado: (2022)

Clinical Significance of TDP-43 Neuropathology in Amyotrophic Lateral Sclerosis
por: Cykowski, Matthew D., et al.
Publicado: (2017)

Neuropathologic description of CHCHD10 mutated amyotrophic lateral sclerosis
por: Keith, Julia L., et al.
Publicado: (2020)

Sympathetic neuropathology is revealed in muscles affected by amyotrophic lateral sclerosis
por: Mazzaro, Antonio, et al.
Publicado: (2023)

Cognitive decline in amyotrophic lateral sclerosis: Neuropathological substrate and genetic determinants
por: Borrego‐Écija, Sergi, et al.
Publicado: (2021)

Dysregulation of Mdm2 and Mdm4 alternative splicing underlies motor neuron death in spinal muscular atrophy
por: Van Alstyne, Meaghan, et al.
Publicado: (2018)

Motor neuron vulnerability and resistance in amyotrophic lateral sclerosis
por: Nijssen, Jik, et al.
Publicado: (2017)

Motor neuron replacement therapy for amyotrophic lateral sclerosis
por: Liu, Bochao, et al.
Publicado: (2022)

Nutrient Effects on Motor Neurons and the Risk of Amyotrophic Lateral Sclerosis
por: Goncharova, Polina S., et al.
Publicado: (2021)

Molecular Motor Proteins and Amyotrophic Lateral Sclerosis
por: Soo, Kai Y, et al.
Publicado: (2011)

Axonal Dysfunction Precedes Motor Neuronal Death in Amyotrophic Lateral Sclerosis
por: Iwai, Yuta, et al.
Publicado: (2016)

Pathogenic Genome Signatures That Damage Motor Neurons in Amyotrophic Lateral Sclerosis
por: Yousefian-Jazi, Ali, et al.
Publicado: (2020)

Upper Motor Neuron Disorders: Primary Lateral Sclerosis, Upper Motor Neuron Dominant Amyotrophic Lateral Sclerosis, and Hereditary Spastic Paraplegia
por: Fullam, Timothy, et al.
Publicado: (2021)

Frontotemporal dementia and amyotrophic lateral sclerosis: revisiting one of the first case reports with neuropathology examination
por: Nitrini, Ricardo
Publicado: (2014)

Impaired Structural Motor Connectome in Amyotrophic Lateral Sclerosis
por: Verstraete, Esther, et al.
Publicado: (2011)

Amyotrophic lateral sclerosis: a dying motor unit?
por: Piotrkiewicz, Maria, et al.
Publicado: (2013)

Regional motor cortex dysfunction in amyotrophic lateral sclerosis
por: Menon, Parvathi, et al.
Publicado: (2019)

Directly converted patient-specific induced neurons mirror the neuropathology of FUS with disrupted nuclear localization in amyotrophic lateral sclerosis
por: Lim, Su Min, et al.
Publicado: (2016)

Psychiatric Symptoms in Amyotrophic Lateral Sclerosis: Beyond a Motor Neuron Disorder
por: Zucchi, Elisabetta, et al.
Publicado: (2019)

Amyotrophic Lateral Sclerosis: A Neurodegenerative Motor Neuron Disease With Ocular Involvement
por: Rojas, Pilar, et al.
Publicado: (2020)

Omics Approach to Axonal Dysfunction of Motor Neurons in Amyotrophic Lateral Sclerosis (ALS)
por: Suzuki, Naoki, et al.
Publicado: (2020)

Amyotrophic lateral sclerosis, a neurodegenerative motor neuron disease with retinal involvement
por: Ramírez, Ana I., et al.
Publicado: (2021)

Bisperoxovanadium promotes motor neuron survival and neuromuscular innervation in amyotrophic lateral sclerosis
por: Wang, Junmei, et al.
Publicado: (2021)

Glucocerebrosidase modulates cognitive and motor activities in murine models of Parkinson’s disease
por: Rockenstein, Edward, et al.
Publicado: (2016)

Murine Models of Lysosomal Storage Diseases Exhibit Differences in Brain Protein Aggregation and Neuroinflammation
por: Clarke, Jennifer, et al.
Publicado: (2021)

“Switchboard” malfunction in motor neuron diseases: Selective pathology of thalamic nuclei in amyotrophic lateral sclerosis and primary lateral sclerosis
por: Chipika, Rangariroyashe H., et al.
Publicado: (2020)

Progressive brainstem pathology in motor neuron diseases: Imaging data from amyotrophic lateral sclerosis and primary lateral sclerosis
por: Bede, Peter, et al.
Publicado: (2020)

Complement activation at the motor end-plates in amyotrophic lateral sclerosis
por: Bahia El Idrissi, Nawal, et al.
Publicado: (2016)

Investigation of non-motor symptoms in patients with amyotrophic lateral sclerosis
por: Hirayama, Takehisa, et al.
Publicado: (2022)

Serum naturally occurring anti-TDP-43 auto-antibodies are increased in amyotrophic lateral sclerosis
por: Conti, Elisa, et al.
Publicado: (2021)

Amyotrophic lateral sclerosis
por: Wijesekera, Lokesh C, et al.
Publicado: (2009)

Dysregulation of the Autophagy-Endolysosomal System in Amyotrophic Lateral Sclerosis and Related Motor Neuron Diseases
por: Otomo, Asako, et al.
Publicado: (2012)

Cellular and molecular mechanisms of motor neuron death in amyotrophic lateral sclerosis: a perspective
por: Tapia, Ricardo
Publicado: (2014)

Motor neuron degeneration in spastic paraplegia 11 mimics amyotrophic lateral sclerosis lesions
por: Denora, Paola S., et al.
Publicado: (2016)

Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis
por: Allen, Scott P, et al.
Publicado: (2019)

Progress in respiratory management of bulbar complications of motor neuron disease/amyotrophic lateral sclerosis?
por: Simonds, Anita K
Publicado: (2017)

Altered Intracellular Milieu of ADAR2-Deficient Motor Neurons in Amyotrophic Lateral Sclerosis
por: Yamashita, Takenari, et al.
Publicado: (2017)

Glutathione S-Transferase Rescues Motor Neuronal Toxicity in Fly Model of Amyotrophic Lateral Sclerosis
por: Cha, Sun Joo, et al.
Publicado: (2020)

Mending the broken in amyotrophic lateral sclerosis: DNA damage and repair in motor neuron degeneration
por: Kim, Byung Woo, et al.
Publicado: (2020)

Lower and upper motor neuron involvement and their impact on disease prognosis in amyotrophic lateral sclerosis
por: Zakharova, Maria N., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_jl9r60midqepqgt6rsevrcbthl