Cargando…

Autophagy is deregulated in cancer-associated fibroblasts from oral cancer and is stimulated during the induction of fibroblast senescence by TGF-β1

Many of the characteristics ascribed to cancer-associated fibroblasts (CAFs) are shared by activated, autophagic and senescent fibroblasts. Whilst most oral squamous cell carcinomas (OSCCs) are genetically unstable (GU-OSCC), genetically stable variants (GS-OSCC) have been described and, notably, CA...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tan, May Leng, Parkinson, E. Kenneth, Yap, Lee Fah, Paterson, Ian C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804411/ https://www.ncbi.nlm.nih.gov/pubmed/33436723 http://dx.doi.org/10.1038/s41598-020-79789-8

Ejemplares similares

Author Correction: Autophagy is deregulated in cancer-associated fibroblasts from oral cancer and is stimulated during the induction of fibroblast senescence by TGF-β1
por: Tan, May Leng, et al.
Publicado: (2022)

The induction of the fibroblast extracellular senescence metabolome is a dynamic process
por: James, Emma N. L., et al.
Publicado: (2018)

Deregulation of lysophosphatidic acid metabolism in oral cancer promotes cell migration via the up-regulation of COX-2
por: Abdul Rahman, Mariati, et al.
Publicado: (2020)

The Dynamic Roles of TGF-β Signalling in EBV-Associated Cancers
por: Velapasamy, Sharmila, et al.
Publicado: (2018)

Induction of Senescence by Loss of Gata4 in Cardiac Fibroblasts
por: Zhang, Zhentao, et al.
Publicado: (2023)

Autophagy Impairment Induces Premature Senescence in Primary Human Fibroblasts
por: Kang, Hyun Tae, et al.
Publicado: (2011)

Phytocannabinoids Stimulate Rejuvenation and Prevent Cellular Senescence in Human Dermal Fibroblasts
por: Gerasymchuk, Marta, et al.
Publicado: (2022)

Chitosan Treatment Delays the Induction of Senescence in Human Foreskin Fibroblast Strains
por: Tsai, Ching-Wen, et al.
Publicado: (2015)

A miR-335/COX-2/PTEN axis regulates the secretory phenotype of senescent cancer-associated fibroblasts
por: Kabir, Tasnuva D., et al.
Publicado: (2016)

Senescent cancer-associated fibroblasts secrete active MMP-2 that promotes keratinocyte dis-cohesion and invasion
por: Hassona, Y, et al.
Publicado: (2014)

Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis
por: Mellone, Massimiliano, et al.
Publicado: (2016)

Protocol to establish cancer-associated fibroblasts from surgically resected tissues and generate senescent fibroblasts
por: Yasuda, Tadahito, et al.
Publicado: (2021)

Transient induction of telomerase expression mediates senescence and reduces tumorigenesis in primary fibroblasts
por: Sun, Linlin, et al.
Publicado: (2019)

The activin-follistatin anti-inflammatory cycle is deregulated in synovial fibroblasts
por: Diller, Magnus, et al.
Publicado: (2019)

The effects and the mechanisms of autophagy on the cancer-associated fibroblasts in cancer
por: Yan, Yuanliang, et al.
Publicado: (2019)

Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production
por: Capparelli, Claudia, et al.
Publicado: (2012)

GALC Triggers Tumorigenicity of Colorectal Cancer via Senescent Fibroblasts
por: Yang, Mengdi, et al.
Publicado: (2020)

Ginsenoside Rb2 suppresses cellular senescence of human dermal fibroblasts by inducing autophagy
por: Yang, Kyeong Eun, et al.
Publicado: (2023)

Deregulation of ATG9A by impaired AR signaling induces autophagy in prostate stromal fibroblasts and promotes BPH progression
por: Jiang, Chen-Yi, et al.
Publicado: (2018)

Modeling of the Senescence-Associated Phenotype in Human Skin Fibroblasts
por: Gerasymchuk, Marta, et al.
Publicado: (2022)

The impact of cellular senescence and senescence‑associated secretory phenotype in cancer‑associated fibroblasts on the malignancy of pancreatic cancer
por: Higashiguchi, Masaya, et al.
Publicado: (2023)

TGF-β1 Activates Nasal Fibroblasts through the Induction of Endoplasmic Reticulum Stress
por: Shin, Jae-Min, et al.
Publicado: (2020)

Fibroblast Senescence in Idiopathic Pulmonary Fibrosis
por: Lin, Yifan, et al.
Publicado: (2020)

TGF-β1-mediated transition of resident fibroblasts to cancer-associated fibroblasts promotes cancer metastasis in gastrointestinal stromal tumor
por: Yoon, Hyunho, et al.
Publicado: (2021)

Autophagy is involved in TGF-β1-induced protective mechanisms and formation of cancer-associated fibroblasts phenotype in tumor microenvironment
por: Liu, Fang-Lan, et al.
Publicado: (2015)

Induction of senescence in primary glioblastoma cells by serum and TGFβ
por: Kumar, Ritesh, et al.
Publicado: (2017)

TGF-β Mediated Immune Evasion in Cancer—Spotlight on Cancer-Associated Fibroblasts
por: Ghahremanifard, Parisa, et al.
Publicado: (2020)

Cancer Stem Cell-Inducing Media Activates Senescence Reprogramming in Fibroblasts
por: Perrigue, Patrick M., et al.
Publicado: (2020)

Heterogeneity in Pancreatic Cancer Fibroblasts—TGFβ as a Master Regulator?
por: Watt, Dale M., et al.
Publicado: (2021)

Gasotransmitter CO Attenuates Bleomycin-Induced Fibroblast Senescence via Induction of Stress Granule Formation
por: Chen, Yingqing, et al.
Publicado: (2021)

Suppression of TGFβ-mediated conversion of endothelial cells and fibroblasts into cancer associated (myo)fibroblasts via HDAC inhibition
por: Kim, Dae Joong, et al.
Publicado: (2018)

Replicatively senescent human fibroblasts reveal a distinct intracellular metabolic profile with alterations in NAD+ and nicotinamide metabolism
por: James, Emma L., et al.
Publicado: (2016)

Dihydroartemisinin Inhibits TGF-β-Induced Fibrosis in Human Tenon Fibroblasts via Inducing Autophagy
por: Wang, Xiaoyuan, et al.
Publicado: (2021)

Dysregulation of autocrine TGF-beta isoform production and ligand responses in human tumour-derived and Ha-ras-transfected keratinocytes and fibroblasts.
por: Fahey, M. S., et al.
Publicado: (1996)

CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth
por: Capparelli, Claudia, et al.
Publicado: (2012)

Deregulation of selective autophagy during aging and pulmonary fibrosis: the role of TGFβ1
por: Sosulski, Meredith L, et al.
Publicado: (2015)

Effects of Oleo Gum Resin of Ferula assa-foetida L. on Senescence in Human Dermal Fibroblasts: - Asafoetida reverses senescence in fibroblasts -
por: Moghadam, Farshad Homayouni, et al.
Publicado: (2017)

Cancer-associated fibroblasts promote malignant phenotypes of prostate cancer cells via autophagy: Cancer-associated fibroblasts promote prostate cancer development
por: Liu, XuKai, et al.
Publicado: (2023)

Snail suppresses cellular senescence and promotes fibroblast‐led cancer cell invasion
por: Furuya, Satoshi, et al.
Publicado: (2017)

Cancer Associated Fibroblasts and Senescent Thyroid Cells in the Invasive Front of Thyroid Carcinoma
por: Minna, Emanuela, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_b2ap1l8ovd10unq8q7j7pjip51