Novel pharmacotherapy: NNI-362, an allosteric p70S6 kinase stimulator, reverses cognitive and neural regenerative deficits in models of aging and disease

Aging is known to slow the neurogenic capacity of the hippocampus, one of only two mammalian adult neurogenic niches. The reduction of adult-born neurons with age may initiate cognitive decline progression which is exacerbated in chronic neurodegenerative disorders, e.g., Alzheimer’s disease (AD). W...

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Detalles Bibliográficos
Autores principales: Sumien, Nathalie, Wells, Matthew S., Sidhu, Akram, Wong, Jessica M., Forster, Michael J., Zheng, Qiao-Xi, Kelleher-Andersson, Judith A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805132/
https://www.ncbi.nlm.nih.gov/pubmed/33436007
http://dx.doi.org/10.1186/s13287-020-02126-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805132/
https://www.ncbi.nlm.nih.gov/pubmed/33436007
http://dx.doi.org/10.1186/s13287-020-02126-3

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