Drug perturbation gene set enrichment analysis (dpGSEA): a new transcriptomic drug screening approach

BACKGROUND: In this study, we demonstrate that our modified Gene Set Enrichment Analysis (GSEA) method, drug perturbation GSEA (dpGSEA), can detect phenotypically relevant drug targets through a unique transcriptomic enrichment that emphasizes biological directionality of drug-derived gene sets. RES...

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Detalles Bibliográficos
Autores principales: Fang, Mike, Richardson, Brian, Cameron, Cheryl M., Dazard, Jean-Eudes, Cameron, Mark J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805197/
https://www.ncbi.nlm.nih.gov/pubmed/33435872
http://dx.doi.org/10.1186/s12859-020-03929-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805197/
https://www.ncbi.nlm.nih.gov/pubmed/33435872
http://dx.doi.org/10.1186/s12859-020-03929-0

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