Double stranded RNA drives innate immune responses, sickness behavior and cognitive impairment dependent on dsRNA length, IFNAR1 expression and age.

Double stranded RNA is generated during viral replication. The synthetic analogue poly I:C is frequently used to mimic anti-viral innate immune responses in models of psychiatric and neurodegenerative disorders including schizophrenia, autism, Parkinson’s disease and Alzheimer’s disease. Many studie...

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Detalles Bibliográficos
Autores principales: McGarry, Niamh, Murray, Carol L., Garvey, Sean, Wilkinson, Abigail, Tortorelli, Lucas, Ryan, Lucy, Hayden, Lorna, Healy, Daire, Griffin, Eadaoin. W., Hennessy, Edel, Arumugam, Malathy, Skelly, Donal T., Mitchell, Kevin J., Cunningham, Colm
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805443/
https://www.ncbi.nlm.nih.gov/pubmed/33442686
http://dx.doi.org/10.1101/2021.01.09.426034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805443/
https://www.ncbi.nlm.nih.gov/pubmed/33442686
http://dx.doi.org/10.1101/2021.01.09.426034

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