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Double stranded RNA drives innate immune responses, sickness behavior and cognitive impairment dependent on dsRNA length, IFNAR1 expression and age.
Double stranded RNA is generated during viral replication. The synthetic analogue poly I:C is frequently used to mimic anti-viral innate immune responses in models of psychiatric and neurodegenerative disorders including schizophrenia, autism, Parkinson’s disease and Alzheimer’s disease. Many studie...
Autores principales: | McGarry, Niamh, Murray, Carol L., Garvey, Sean, Wilkinson, Abigail, Tortorelli, Lucas, Ryan, Lucy, Hayden, Lorna, Healy, Daire, Griffin, Eadaoin. W., Hennessy, Edel, Arumugam, Malathy, Skelly, Donal T., Mitchell, Kevin J., Cunningham, Colm |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805443/ https://www.ncbi.nlm.nih.gov/pubmed/33442686 http://dx.doi.org/10.1101/2021.01.09.426034 |
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