Molecular dynamics simulations and functional studies reveal that hBD-2 binds SARS-CoV-2 spike RBD and blocks viral entry into ACE2 expressing cells

New approaches to complement vaccination are needed to combat the spread of SARS-CoV-2 and stop COVID-19 related deaths and long-term medical complications. Human beta defensin 2 (hBD-2) is a naturally occurring epithelial cell derived host defense peptide that has antiviral properties. Our comprehe...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Liqun, Ghosh, Santosh K., Basavarajappa, Shrikanth C., Muller-Greven, Jeannine, Penfield, Jackson, Brewer, Ann, Ramakrishnan, Parameswaran, Buck, Matthias, Weinberg, Aaron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805467/
https://www.ncbi.nlm.nih.gov/pubmed/33442698
http://dx.doi.org/10.1101/2021.01.07.425621

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805467/
https://www.ncbi.nlm.nih.gov/pubmed/33442698
http://dx.doi.org/10.1101/2021.01.07.425621

Ejemplares similares