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Molecular dynamics simulations and functional studies reveal that hBD-2 binds SARS-CoV-2 spike RBD and blocks viral entry into ACE2 expressing cells

New approaches to complement vaccination are needed to combat the spread of SARS-CoV-2 and stop COVID-19 related deaths and long-term medical complications. Human beta defensin 2 (hBD-2) is a naturally occurring epithelial cell derived host defense peptide that has antiviral properties. Our comprehe...

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Detalles Bibliográficos
Autores principales:	Zhang, Liqun, Ghosh, Santosh K., Basavarajappa, Shrikanth C., Muller-Greven, Jeannine, Penfield, Jackson, Brewer, Ann, Ramakrishnan, Parameswaran, Buck, Matthias, Weinberg, Aaron
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805467/ https://www.ncbi.nlm.nih.gov/pubmed/33442698 http://dx.doi.org/10.1101/2021.01.07.425621

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