8-cyanobenzothiazinone analogs with potent antitubercular activity

8-Nitrobenzothiazinones (BTZs) exemplified by macozinone are a new class of antitubercular agents with exceptionally potent activity. The aryl nitro group has been considered indispensable for activity since this is bioactivated within mycobacteria by the flavoenzyme DprE1 to a reactive nitroso meta...

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Detalles Bibliográficos
Autores principales: Zhang, Gang, Sheng, Li, Hegde, Pooja, Li, Yan, Aldrich, Courtney C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805566/
https://www.ncbi.nlm.nih.gov/pubmed/33462533
http://dx.doi.org/10.1007/s00044-020-02676-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805566/
https://www.ncbi.nlm.nih.gov/pubmed/33462533
http://dx.doi.org/10.1007/s00044-020-02676-4

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