A Single Immunization with Spike-Functionalized Ferritin Vaccines Elicits Neutralizing Antibody Responses against SARS-CoV-2 in Mice

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[Image: see text] The development of a safe and effective SARS-CoV-2 vaccine is a public health priority. We designed subunit vaccine candidates using self-assembling ferritin nanoparticles displaying one of two multimerized SARS-CoV-2 spikes: full-length ectodomain (S-Fer) or a C-terminal 70 amino-...

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Detalles Bibliográficos
Autores principales: Powell, Abigail E., Zhang, Kaiming, Sanyal, Mrinmoy, Tang, Shaogeng, Weidenbacher, Payton A., Li, Shanshan, Pham, Tho D., Pak, John E., Chiu, Wah, Kim, Peter S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805605/
https://www.ncbi.nlm.nih.gov/pubmed/33527087
http://dx.doi.org/10.1021/acscentsci.0c01405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805605/
https://www.ncbi.nlm.nih.gov/pubmed/33527087
http://dx.doi.org/10.1021/acscentsci.0c01405

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