Cell cycle inertia underlies a bifurcation in cell fates after DNA damage

The G(1)-S checkpoint is thought to prevent cells with damaged DNA from entering S phase and replicating their DNA and efficiently arrests cells at the G(1)-S transition. Here, using time-lapse imaging and single-cell tracking, we instead find that DNA damage leads to highly variable and divergent f...

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Detalles Bibliográficos
Autores principales: Nathans, Jenny F., Cornwell, James A., Afifi, Marwa M., Paul, Debasish, Cappell, Steven D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806216/
https://www.ncbi.nlm.nih.gov/pubmed/33523889
http://dx.doi.org/10.1126/sciadv.abe3882

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806216/
https://www.ncbi.nlm.nih.gov/pubmed/33523889
http://dx.doi.org/10.1126/sciadv.abe3882

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