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Cell cycle inertia underlies a bifurcation in cell fates after DNA damage
The G(1)-S checkpoint is thought to prevent cells with damaged DNA from entering S phase and replicating their DNA and efficiently arrests cells at the G(1)-S transition. Here, using time-lapse imaging and single-cell tracking, we instead find that DNA damage leads to highly variable and divergent f...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806216/ https://www.ncbi.nlm.nih.gov/pubmed/33523889 http://dx.doi.org/10.1126/sciadv.abe3882 |