SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site

Coronavirus entry is mediated by the spike protein that binds the receptor and mediates fusion after cleavage by host proteases. The proteases that mediate entry differ between cell lines, and it is currently unclear which proteases are relevant in vivo. A remarkable feature of the severe acute resp...

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Detalles Bibliográficos
Autores principales: Mykytyn, Anna Z, Breugem, Tim I, Riesebosch, Samra, Schipper, Debby, van den Doel, Petra B, Rottier, Robbert J, Lamers, Mart M, Haagmans, Bart L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806259/
https://www.ncbi.nlm.nih.gov/pubmed/33393462
http://dx.doi.org/10.7554/eLife.64508

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806259/
https://www.ncbi.nlm.nih.gov/pubmed/33393462
http://dx.doi.org/10.7554/eLife.64508

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