Histone demethylase JMJD3 protects against renal fibrosis by suppressing TGFβ and Notch signaling and preserving PTEN expression

Rationale: The Jumonji domain containing-3 (JMJD3), a specific histone demethylase for trimethylation on histone H3 lysine 27 (H3K27me3), is associated with the pathogenesis of many diseases, but its role in renal fibrosis remains unexplored. Here we examined the role of JMJD3 and mechanisms involve...

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Detalles Bibliográficos
Autores principales: Yu, Chao, Xiong, Chongxiang, Tang, Jinhua, Hou, Xiying, Liu, Na, Bayliss, George, Zhuang, Shougang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806480/
https://www.ncbi.nlm.nih.gov/pubmed/33456568
http://dx.doi.org/10.7150/thno.48679

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806480/
https://www.ncbi.nlm.nih.gov/pubmed/33456568
http://dx.doi.org/10.7150/thno.48679

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