Cargando…

Smad3 deficiency promotes beta cell proliferation and function in db/db mice via restoring Pax6 expression

Rationale: Transforming Growth Factor-beta (TGF-β) /Smad3 signaling has been shown to play important roles in fibrotic and inflammatory diseases, but its role in beta cell function and type 2 diabetes is unknown. Methods: The role of Smad3 in beta cell function under type 2 diabetes condition was in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sheng, Jingyi, Wang, Li, Tang, Patrick Ming-Kuen, Wang, Hong-Lian, Li, Jian-Chun, Xu, Bi-Hua, Xue, Vivian Weiwen, Tan, Rui-Zhi, Jin, Nana, Chan, Ting-Fung, Huang, Xiao-Ru, Ma, Ronald CW, Lan, Hui-Yao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806493/ https://www.ncbi.nlm.nih.gov/pubmed/33456576 http://dx.doi.org/10.7150/thno.51857

Ejemplares similares

AANG Prevents Smad3-dependent Diabetic Nephropathy by Restoring Pancreatic β-Cell Development in db/db Mice
por: Chung, Jeff Yat-Fai, et al.
Publicado: (2022)

Smad3 Mediates Diabetic Dyslipidemia and Fatty Liver in db/db Mice by Targeting PPARδ
por: He, Huijun, et al.
Publicado: (2023)

Deletion of Smad3 protects against diabetic myocardiopathy in db/db mice
por: Dong, Li, et al.
Publicado: (2021)

Renoprotective Effect of Formononetin by Suppressing Smad3 Expression in Db/Db Mice
por: Lv, Jiawei, et al.
Publicado: (2020)

Huangqi decoction ameliorates kidney injury in db/db mice by regulating the BMP/Smad signaling pathway
por: Chen, Ying, et al.
Publicado: (2023)

Characterisation of Age-Dependent Beta Cell Dynamics in the Male db/db Mice
por: Dalbøge, Louise S., et al.
Publicado: (2013)

Xiaokeping Mixture Attenuates Diabetic Kidney Disease by Modulating TGF-β/Smad Pathway in db/db Mice
por: Yang, Bo, et al.
Publicado: (2019)

Dendrobium Mixture Ameliorates Diabetic Nephropathy in db/db Mice by Regulating the TGF-β1/Smads Signaling Pathway
por: Chen, Yong, et al.
Publicado: (2021)

Alterations of the Ca(2+) signaling pathway in pancreatic beta-cells isolated from db/db mice
por: Liang, Kuo, et al.
Publicado: (2014)

Cosmos DB for MongoDB developers: migrating to Azure Cosmos DB and using the MongoDB API
por: Sharma, Manish
Publicado: (2018)

Validity of leptin receptor-deficiency (db/db) type 2 diabetes mellitus mice as a model of secondary osteoporosis
por: Huang, Le, et al.
Publicado: (2016)

Curcumin restores mitochondrial functions and decreases lipid peroxidation in liver and kidneys of diabetic db/db mice
por: Soto-Urquieta, María G, et al.
Publicado: (2014)

Increased Oxidative Damage of RNA in Early-Stage Nephropathy in db/db Mice
por: Wang, Wan-Xia, et al.
Publicado: (2017)

Astragaloside IV ameliorates renal injury in db/db mice
por: Sun, Huili, et al.
Publicado: (2016)

C-Reactive Protein Promotes Diabetic Kidney Disease in db/db Mice via the CD32b-Smad3-mTOR signaling Pathway
por: You, Yong-Ke, et al.
Publicado: (2016)

Dapagliflozin protects against nonalcoholic steatohepatitis in db/db mice
por: Qiao, Panshuang, et al.
Publicado: (2022)

Anti-diabetic activities of catalpol in db/db mice
por: Bao, Qinwen, et al.
Publicado: (2016)

Luseogliflozin preserves the pancreatic beta-cell mass and function in db/db mice by improving mitochondrial function
por: Yamauchi, Yuki, et al.
Publicado: (2022)

PaxDb, a Database of Protein Abundance Averages Across All Three Domains of Life
por: Wang, M., et al.
Publicado: (2012)

Antidiabetic and Antiobesity Effects of Artemether in db/db Mice
por: Guo, Yu, et al.
Publicado: (2018)

Jinlida Granules Reduce Obesity in db/db Mice by Activating Beige Adipocytes
por: Zhou, Hong-ru, et al.
Publicado: (2022)

Zinc Prevents the Development of Diabetic Cardiomyopathy in db/db Mice
por: Wang, Shudong, et al.
Publicado: (2017)

Effect of echinacoside on kidney fibrosis by inhibition of TGF-β1/Smads signaling pathway in the db/db mice model of diabetic nephropathy
por: Tang, Fengjuan, et al.
Publicado: (2017)

Therapeutic Effects of Tangshen Formula on Diabetic Nephropathy in db/db Mice Using Cytokine Antibody Array
por: Fan, Xue Mei, et al.
Publicado: (2018)

Effect of Ezetimibe on Insulin Secretion in db/db Diabetic Mice
por: Zhong, Yong, et al.
Publicado: (2012)

Mibefradil reduces blood glucose concentration in db/db mice
por: Lu, Yujie, et al.
Publicado: (2014)

MG53 Does Not Manifest the Development of Diabetes in db/db Mice
por: Wang, Qiang, et al.
Publicado: (2020)

The secretory deficit in islets from db/db mice is mainly due to a loss of responding beta cells
por: Do, Oanh H., et al.
Publicado: (2014)

Neuregulin 1 Improves Glucose Tolerance in db/db Mice
por: Ennequin, Gaël, et al.
Publicado: (2015)

Debuncher DB1 (DB2 and DB3): 1 A06 - 000 - 1
por: Boltezar, E
Publicado: (1970)

Debuncher DB1 (DB2 and DB3): I A06-000-1
por: Boltezar, E
Publicado: (1970)

PaxDb 5.0: Curated Protein Quantification Data Suggests Adaptive Proteome Changes in Yeasts
por: Huang, Qingyao, et al.
Publicado: (2023)

Gut Microbiota Composition and Structure of the Ob/Ob and Db/Db Mice
por: Yang, Mingsheng, et al.
Publicado: (2019)

Disparate phospho-Smad2 levels in advanced type 2 diabetes patients with diabetic nephropathy and early experimental db/db mouse model
por: Thomsen, Lise Høj, et al.
Publicado: (2017)

Artemether Regulates Metaflammation to Improve Glycolipid Metabolism in db/db Mice
por: Fu, Wei, et al.
Publicado: (2020)

Tangshen Formula Attenuates Diabetic Nephropathy by Promoting ABCA1-Mediated Renal Cholesterol Efflux in db/db Mice
por: Liu, Peng, et al.
Publicado: (2018)

Efficacy of Acetylshikonin in Preventing Obesity and Hepatic Steatosis in db/db Mice
por: Su, Mei-Ling, et al.
Publicado: (2016)

Reintroducing testosterone in the db/db mouse partially restores normal glucose metabolism and insulin resistance in a leptin-independent manner
por: Yabiku, Koichi, et al.
Publicado: (2018)

PHLPP1 deletion restores pancreatic β-cell survival and normoglycemia in the db/db mouse model of obesity-associated diabetes
por: Lupse, Blaz, et al.
Publicado: (2022)

Fecal microbiota transplantation improves metabolism and gut microbiome composition in db/db mice
por: Zhang, Pei-pei, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_5bmgrvfk4emouj99srtepnhspn