Cargando…

Exosome-based Ldlr gene therapy for familial hypercholesterolemia in a mouse model

Familial hypercholesterolemia (FH), with high LDL (low-density lipoprotein) cholesterol levels, is due to inherited mutations in genes, such as low-density lipoprotein receptor (LDLR). Development of therapeutic strategies for FH, which causes atherosclerosis and cardiovascular disease, is urgently...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Zhelong, Zhao, Ping, Zhang, Yajun, Wang, Jia, Wang, Chen, Liu, Yunnan, Yang, Guodong, Yuan, Lijun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806494/ https://www.ncbi.nlm.nih.gov/pubmed/33456582 http://dx.doi.org/10.7150/thno.49874

Ejemplares similares

Exosomes in atherosclerosis: performers, bystanders, biomarkers, and therapeutic targets
por: Wang, Chen, et al.
Publicado: (2021)

LDLR gene’s promoter region hypermethylation in patients with familial hypercholesterolemia
por: Zorzo, R. A., et al.
Publicado: (2023)

Improved extracellular vesicle-based mRNA delivery for familial hypercholesterolemia treatment
por: Yang, Zheng, et al.
Publicado: (2023)

Two Novel Disease-Causing Mutations in the LDLR of Familial Hypercholesterolemia
por: Hu, Haochang, et al.
Publicado: (2021)

Screening and verifying the mutations in the LDLR and APOB genes in a Chinese family with familial hypercholesterolemia
por: Lv, Xian, et al.
Publicado: (2023)

Genomic characterization of large rearrangements of the LDLR gene in Czech patients with familial hypercholesterolemia
por: Goldmann, Radan, et al.
Publicado: (2010)

A Japanese case of familial hypercholesterolemia with a novel mutation in the LDLR gene
por: Nagahara, Keiko, et al.
Publicado: (2019)

Therapeutic targets of hypercholesterolemia: HMGCR and LDLR
por: Ma, Shizhan, et al.
Publicado: (2019)

A novel indel variant in LDLR responsible for familial hypercholesterolemia in a Chinese family
por: Shu, Hongyan, et al.
Publicado: (2017)

Novel Presentation of Homozygous Familial Hypercholesterolemia With Homozygous Variants in Both LDLR and APOB Genes
por: Derenbecker, Robert, et al.
Publicado: (2019)

Use of next-generation sequencing to detect LDLR gene copy number variation in familial hypercholesterolemia
por: Iacocca, Michael A., et al.
Publicado: (2017)

Endoplasmic reticulum quality control of LDLR variants associated with familial hypercholesterolemia
por: Kizhakkedath, Praseetha, et al.
Publicado: (2019)

Brown adipose tissue-derived exosomes mitigate the metabolic syndrome in high fat diet mice
por: Zhou, Xueying, et al.
Publicado: (2020)

In vitro assessment of the pathogenicity of the LDLR c.2160delC variant in familial hypercholesterolemia
por: Lin, Shaoyi, et al.
Publicado: (2023)

Identification of novel variants in the LDLR gene in Russian patients with familial hypercholesterolemia using targeted sequencing
por: Miroshnikova, Valentina V., et al.
Publicado: (2021)

Analysis of the low density lipoprotein receptor gene (LDLR) mutation spectrum in Russian familial hypercholesterolemia
por: Vasilyev, V.B., et al.
Publicado: (2022)

The LDLR c.501C>A is a disease-causing variant in familial hypercholesterolemia
por: Hu, Haochang, et al.
Publicado: (2021)

The LDLR, APOB, and PCSK9 Variants of Index Patients with Familial Hypercholesterolemia in Russia
por: Meshkov, Alexey, et al.
Publicado: (2021)

Validation of LDLr Activity as a Tool to Improve Genetic Diagnosis of Familial Hypercholesterolemia: A Retrospective on Functional Characterization of LDLr Variants
por: Benito-Vicente, Asier, et al.
Publicado: (2018)

Decreased serum PON1 arylesterase activity in familial hypercholesterolemia patients with a mutated LDLR gene
por: Idrees, Muhammad, et al.
Publicado: (2018)

Ultrasound triggered topical delivery of Bmp7 mRNA for white fat browning induction via engineered smart exosomes
por: Guo, Yitong, et al.
Publicado: (2021)

Multifaceted Roles of Adipose Tissue-Derived Exosomes in Physiological and Pathological Conditions
por: Liu, Yunnan, et al.
Publicado: (2021)

Spontaneous severe hypercholesterolemia and atherosclerosis lesions in rabbits with deficiency of low-density lipoprotein receptor (LDLR) on exon 7
por: Lu, Rui, et al.
Publicado: (2018)

Genetic Polymorphisms in LDLR, APOB, PCSK9 and Other Lipid Related Genes Associated with Familial Hypercholesterolemia in Malaysia
por: Lye, Say-Hean, et al.
Publicado: (2013)

Erratum: Decreased serum PON1 arylesterase activity in familial hypercholesterolemia patients with a mutated LDLR gene
Publicado: (2019)

Patients With LDLR and PCSK9 Gene Variants Experienced Higher Incidence of Cardiovascular Outcomes in Heterozygous Familial Hypercholesterolemia
por: Doi, Takahito, et al.
Publicado: (2021)

Novel LDLR Variant in Familial Hypercholesterolemia: NGS-Based Identification, In Silico Characterization, and Pharmacogenetic Insights
por: Athar, Mohammad, et al.
Publicado: (2023)

Targeted Disruption of LDLR Causes Hypercholesterolemia and Atherosclerosis in Yucatan Miniature Pigs
por: Davis, Bryan T., et al.
Publicado: (2014)

A Rare Missense Mutation and a Polymorphism with High Frequency in LDLR Gene among Iranian Patients with Familial Hypercholesterolemia
por: Tajamolian, Masoud, et al.
Publicado: (2018)

Mutational Spectrum of LDLR and PCSK9 Genes Identified in Iranian Patients With Premature Coronary Artery Disease and Familial Hypercholesterolemia
por: Moradi, Arman, et al.
Publicado: (2021)

Exosome-mediated delivery of inflammation-responsive Il-10 mRNA for controlled atherosclerosis treatment
por: Bu, Te, et al.
Publicado: (2021)

Efficient exosome delivery in refractory tissues assisted by ultrasound-targeted microbubble destruction
por: Sun, Wenqi, et al.
Publicado: (2019)

Identification of a novel nonsense variant c.1332dup, p.(D445*) in the LDLR gene that causes familial hypercholesterolemia
por: Al-Allaf, Faisal A, et al.
Publicado: (2014)

Functional Analysis of LDLR (Low-Density Lipoprotein Receptor) Variants in Patient Lymphocytes to Assess the Effect of Evinacumab in Homozygous Familial Hypercholesterolemia Patients With a Spectrum of LDLR Activity
por: Banerjee, Poulabi, et al.
Publicado: (2019)

LDLR-Gene therapy for familial hypercholesterolaemia: problems, progress, and perspectives
por: Al-Allaf, Faisal A, et al.
Publicado: (2010)

Variable expressivity and co‐occurrence of LDLR and LDLRAP1 mutations in familial hypercholesterolemia: failure of the dominant and recessive dichotomy
por: Fahed, Akl C., et al.
Publicado: (2016)

Bioinspired therapeutic platform based on extracellular vesicles for prevention of arterial wall remodeling in hypertension
por: Wang, Chen, et al.
Publicado: (2021)

An LDLR missense variant poses high risk of familial hypercholesterolemia in 30% of Greenlanders and offers potential of early cardiovascular disease intervention
por: Jørsboe, Emil, et al.
Publicado: (2022)

Genetically confirmed familial hypercholesterolemia in outpatients with hypercholesterolemia
por: Wang, Xu, et al.
Publicado: (2018)

A genetic variant in the LDLR promoter is responsible for part of the LDL-cholesterol variability in primary hypercholesterolemia
por: De Castro-Orós, Isabel, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_d7m0m7uav3tkpv1o1oertqbu6g