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Protocol for determining zinc-dependent β cell-selective small-molecule delivery in mouse pancreas
Targeted drug delivery to pancreatic islet β cells is an unmet clinical need. β cells possess a uniquely high Zn(2+) concentration, and integrating Zn(2+)-binding activity into a small molecule can bias drug accumulation and activity toward β cells. This protocol can be used to evaluate a molecule’s...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806521/ https://www.ncbi.nlm.nih.gov/pubmed/33490979 http://dx.doi.org/10.1016/j.xpro.2020.100263 |