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Protocol for determining zinc-dependent β cell-selective small-molecule delivery in mouse pancreas

Targeted drug delivery to pancreatic islet β cells is an unmet clinical need. β cells possess a uniquely high Zn(2+) concentration, and integrating Zn(2+)-binding activity into a small molecule can bias drug accumulation and activity toward β cells. This protocol can be used to evaluate a molecule’s...

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Detalles Bibliográficos
Autores principales: Horton, Timothy M., Kraemer, Benjamin R., Annes, Justin P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806521/
https://www.ncbi.nlm.nih.gov/pubmed/33490979
http://dx.doi.org/10.1016/j.xpro.2020.100263

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