NSC348884 cytotoxicity is not mediated by inhibition of nucleophosmin oligomerization

Nucleophosmin (NPM) mutations causing its export from the nucleoli to the cytoplasm are frequent in acute myeloid leukemia (AML). Due to heterooligomerization of wild type NPM with the AML-related mutant, the wild-type becomes misplaced from the nucleoli and its functions are significantly altered....

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Detalles Bibliográficos
Autores principales: Šašinková, Markéta, Heřman, Petr, Holoubek, Aleš, Strachotová, Dita, Otevřelová, Petra, Grebeňová, Dana, Kuželová, Kateřina, Brodská, Barbora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806638/
https://www.ncbi.nlm.nih.gov/pubmed/33441774
http://dx.doi.org/10.1038/s41598-020-80224-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806638/
https://www.ncbi.nlm.nih.gov/pubmed/33441774
http://dx.doi.org/10.1038/s41598-020-80224-1

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