Graphical analysis for phenome-wide causal discovery in genotyped population-scale biobanks

Causal inference via Mendelian randomization requires making strong assumptions about horizontal pleiotropy, where genetic instruments are connected to the outcome not only through the exposure. Here, we present causal Graphical Analysis Using Genetics (cGAUGE), a pipeline that overcomes these limit...

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Detalles Bibliográficos
Autores principales: Amar, David, Sinnott-Armstrong, Nasa, Ashley, Euan A., Rivas, Manuel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806647/
https://www.ncbi.nlm.nih.gov/pubmed/33441555
http://dx.doi.org/10.1038/s41467-020-20516-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806647/
https://www.ncbi.nlm.nih.gov/pubmed/33441555
http://dx.doi.org/10.1038/s41467-020-20516-2

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