Human α-synuclein overexpression in a mouse model of Parkinson’s disease leads to vascular pathology, blood brain barrier leakage and pericyte activation

The pathological hallmark of Parkinson’s disease (PD) is the formation of Lewy bodies containing aggregated alpha-synuclein (α-syn). Although PD is associated with these distinct histological changes, other pathological features such as microvascular alterations have been linked to neurodegeneration...

Descripción completa

Detalles Bibliográficos
Autores principales: Elabi, Osama, Gaceb, Abderahim, Carlsson, Robert, Padel, Thomas, Soylu-Kucharz, Rana, Cortijo, Irene, Li, Wen, Li, Jia-Yi, Paul, Gesine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806665/
https://www.ncbi.nlm.nih.gov/pubmed/33441868
http://dx.doi.org/10.1038/s41598-020-80889-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806665/
https://www.ncbi.nlm.nih.gov/pubmed/33441868
http://dx.doi.org/10.1038/s41598-020-80889-8

Ejemplares similares