Differential organ-specific inflammatory response to progranulin in high-fat diet-fed mice

Progranulin (PGRN) has been reported to bind tumor necrosis factor (TNF) receptor and to inhibit TNFα signaling. We evaluated the effect of augmentation of TNFα signaling by PGRN deficiency on the progression of kidney injury. Eight-week-old PGRN knockout (KO) and wild-type (WT) mice were fed a stan...

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Detalles Bibliográficos
Autores principales: Murakoshi, Maki, Gohda, Tomohito, Adachi, Eri, Ichikawa, Saki, Hagiwara, Shinji, Suzuki, Yusuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806827/
https://www.ncbi.nlm.nih.gov/pubmed/33441916
http://dx.doi.org/10.1038/s41598-020-80940-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806827/
https://www.ncbi.nlm.nih.gov/pubmed/33441916
http://dx.doi.org/10.1038/s41598-020-80940-8

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