Overcoming hypoxia-induced resistance of pancreatic and lung tumor cells by disrupting the PERK-NRF2-HIF-axis

Hypoxia-induced resistance of tumor cells to therapeutic treatment is an unresolved limitation due to poor vascular accessibility and protective cell adaptations provided by a network, including PERK, NRF2, and HIF signaling. All three pathways have been shown to influence each other, but a detailed...

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Detalles Bibliográficos
Autores principales: Küper, Alina, Baumann, Jennifer, Göpelt, Kirsten, Baumann, Melanie, Sänger, Christopher, Metzen, Eric, Kranz, Philip, Brockmeier, Ulf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806930/
https://www.ncbi.nlm.nih.gov/pubmed/33441543
http://dx.doi.org/10.1038/s41419-020-03319-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806930/
https://www.ncbi.nlm.nih.gov/pubmed/33441543
http://dx.doi.org/10.1038/s41419-020-03319-7

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