FV-429 induces autophagy blockage and lysosome-dependent cell death of T-cell malignancies via lysosomal dysregulation

It is widely accepted that lysosomes are essential for cell homeostasis, and autophagy plays an important role in tumor development. Here, we found FV-429, a synthetic flavonoid compound, inhibited autophagy flux, promoted autophagosomes accumulation, and inhibited lysosomal degradation in T-cell ma...

Descripción completa

Detalles Bibliográficos
Autores principales: Hu, Po, Wang, Jubo, Qing, Yingjie, Li, Hui, Sun, Wenzhuo, Yu, Xiaoxuan, Hui, Hui, Guo, Qinglong, Xu, Jingyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806986/
https://www.ncbi.nlm.nih.gov/pubmed/33441536
http://dx.doi.org/10.1038/s41419-021-03394-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806986/
https://www.ncbi.nlm.nih.gov/pubmed/33441536
http://dx.doi.org/10.1038/s41419-021-03394-4

Ejemplares similares