Intranasal administration of α-synuclein preformed fibrils triggers microglial iron deposition in the substantia nigra of Macaca fascicularis

Iron deposition is present in main lesion areas in the brains of patients with Parkinson’s disease (PD) and an abnormal iron content may be associated with dopaminergic neuronal cytotoxicity and degeneration in the substantia nigra of the midbrain. However, the cause of iron deposition and its role...

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Detalles Bibliográficos
Autores principales: Guo, Jian-Jun, Yue, Feng, Song, Dong-Yan, Bousset, Luc, Liang, Xin, Tang, Jing, Yuan, Lin, Li, Wen, Melki, Ronald, Tang, Yong, Chan, Piu, Guo, Chuang, Li, Jia-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807015/
https://www.ncbi.nlm.nih.gov/pubmed/33441545
http://dx.doi.org/10.1038/s41419-020-03369-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807015/
https://www.ncbi.nlm.nih.gov/pubmed/33441545
http://dx.doi.org/10.1038/s41419-020-03369-x

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