Enhanced oncolytic adenoviral production by downregulation of death-domain associated protein and overexpression of precursor terminal protein

Adequate viral replication in tumor cells is the key to improving the anti-cancer effects of oncolytic adenovirus therapy. In this study, we introduced short hairpin RNAs against death-domain associated protein (Daxx), a repressor of adenoviral replication, and precursor terminal protein (pTP), an i...

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Detalles Bibliográficos
Autores principales: Lee, Jihyun, Oh, Geun-Hyeok, Hong, Jeong A., Choi, Soojin, Choi, Hye Jin, Song, Jae J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807022/
https://www.ncbi.nlm.nih.gov/pubmed/33441685
http://dx.doi.org/10.1038/s41598-020-79998-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807022/
https://www.ncbi.nlm.nih.gov/pubmed/33441685
http://dx.doi.org/10.1038/s41598-020-79998-1

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