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Enhanced oncolytic adenoviral production by downregulation of death-domain associated protein and overexpression of precursor terminal protein
Adequate viral replication in tumor cells is the key to improving the anti-cancer effects of oncolytic adenovirus therapy. In this study, we introduced short hairpin RNAs against death-domain associated protein (Daxx), a repressor of adenoviral replication, and precursor terminal protein (pTP), an i...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807022/ https://www.ncbi.nlm.nih.gov/pubmed/33441685 http://dx.doi.org/10.1038/s41598-020-79998-1 |