Age-related and disease locus-specific mechanisms contribute to early remodelling of chromatin structure in Huntington’s disease mice

Temporal dynamics and mechanisms underlying epigenetic changes in Huntington’s disease (HD), a neurodegenerative disease primarily affecting the striatum, remain unclear. Using a slowly progressing knockin mouse model, we profile the HD striatal chromatin landscape at two early disease stages. Data...

Descripción completa

Detalles Bibliográficos
Autores principales: Alcalá-Vida, Rafael, Seguin, Jonathan, Lotz, Caroline, Molitor, Anne M., Irastorza-Azcarate, Ibai, Awada, Ali, Karasu, Nezih, Bombardier, Aurélie, Cosquer, Brigitte, Skarmeta, Jose Luis Gomez, Cassel, Jean-Christophe, Boutillier, Anne-Laurence, Sexton, Thomas, Merienne, Karine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807045/
https://www.ncbi.nlm.nih.gov/pubmed/33441541
http://dx.doi.org/10.1038/s41467-020-20605-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807045/
https://www.ncbi.nlm.nih.gov/pubmed/33441541
http://dx.doi.org/10.1038/s41467-020-20605-2

Ejemplares similares