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Age-related and disease locus-specific mechanisms contribute to early remodelling of chromatin structure in Huntington’s disease mice

Temporal dynamics and mechanisms underlying epigenetic changes in Huntington’s disease (HD), a neurodegenerative disease primarily affecting the striatum, remain unclear. Using a slowly progressing knockin mouse model, we profile the HD striatal chromatin landscape at two early disease stages. Data...

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Detalles Bibliográficos
Autores principales:	Alcalá-Vida, Rafael, Seguin, Jonathan, Lotz, Caroline, Molitor, Anne M., Irastorza-Azcarate, Ibai, Awada, Ali, Karasu, Nezih, Bombardier, Aurélie, Cosquer, Brigitte, Skarmeta, Jose Luis Gomez, Cassel, Jean-Christophe, Boutillier, Anne-Laurence, Sexton, Thomas, Merienne, Karine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807045/ https://www.ncbi.nlm.nih.gov/pubmed/33441541 http://dx.doi.org/10.1038/s41467-020-20605-2

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