Modulation of cAMP metabolism for CFTR potentiation in human airway epithelial cells

Cystic fibrosis (CF) is a genetic disease characterized by CF transmembrane regulator (CFTR) dysfunction. With over 2000 CFTR variants identified, in addition to known patient to patient variability, there is a need for personalized treatment. The discovery of CFTR modulators has shown efficacy in c...

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Detalles Bibliográficos
Autores principales: Nguyen, Jenny P., Bianca, Matthew, Huff, Ryan D., Tiessen, Nicholas, Inman, Mark D., Hirota, Jeremy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807051/
https://www.ncbi.nlm.nih.gov/pubmed/33441643
http://dx.doi.org/10.1038/s41598-020-79555-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807051/
https://www.ncbi.nlm.nih.gov/pubmed/33441643
http://dx.doi.org/10.1038/s41598-020-79555-w

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