Diagnosis of hypogonadism in patients treated with low energy shock wave therapy for erectile dysfunction: a narrative review
Several methods of treatment of erectile dysfunction (ED) are offered with low energy shock-wave therapy (LESWT) gaining increasing attention. Reports have documented that LESWT stimulates tissue neovascularization, proliferation and differentiation of endothelial cells, and production of nitric oxi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807342/ https://www.ncbi.nlm.nih.gov/pubmed/33457250 http://dx.doi.org/10.21037/tau-20-796 |
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author | Kałka, Dariusz Biernikiewicz, Małgorzata Gebala, Jana Sobieszczańska, Małgorzata Jakima, Sławomir Pilecki, Witold Rusiecki, Lesław |
author_facet | Kałka, Dariusz Biernikiewicz, Małgorzata Gebala, Jana Sobieszczańska, Małgorzata Jakima, Sławomir Pilecki, Witold Rusiecki, Lesław |
author_sort | Kałka, Dariusz |
collection | PubMed |
description | Several methods of treatment of erectile dysfunction (ED) are offered with low energy shock-wave therapy (LESWT) gaining increasing attention. Reports have documented that LESWT stimulates tissue neovascularization, proliferation and differentiation of endothelial cells, and production of nitric oxide - all can improve the condition of erectile tissue. However, the overall and sexual condition of men deteriorates with age which is linked with a constant decrease in testosterone concentration. A higher risk of sexual health disorders and reduced physical fitness correlates with a testosterone concentration of <12 nmol/L. Such patients may require testosterone replacement therapy. We conducted a target literature review to investigate whether testosterone concentration is taken into account in studies on the use of LESWT in the treatment of ED. We found that most studies did not provide any information on testosterone status. Only 8 of 25 studies examined showed values of testosterone concentrations. Only one of these analyses checked the relationship between the efficacy of LESWT and testosterone concentration. As a result, meta-analyses published to date may not show the full value of LESWT in the treatment of ED. We conclude that in the light of the significant role testosterone plays in the process of an erection and the mechanism of LESWT action, it can be recommended to examine testosterone concentration and to diagnose hypogonadism during the qualification of patients to studies on LESWT efficacy. Moreover, the effectiveness of LESWT in relation to the current testosterone concentration should also be further investigated. |
format | Online Article Text |
id | pubmed-7807342 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-78073422021-01-15 Diagnosis of hypogonadism in patients treated with low energy shock wave therapy for erectile dysfunction: a narrative review Kałka, Dariusz Biernikiewicz, Małgorzata Gebala, Jana Sobieszczańska, Małgorzata Jakima, Sławomir Pilecki, Witold Rusiecki, Lesław Transl Androl Urol Review Article Several methods of treatment of erectile dysfunction (ED) are offered with low energy shock-wave therapy (LESWT) gaining increasing attention. Reports have documented that LESWT stimulates tissue neovascularization, proliferation and differentiation of endothelial cells, and production of nitric oxide - all can improve the condition of erectile tissue. However, the overall and sexual condition of men deteriorates with age which is linked with a constant decrease in testosterone concentration. A higher risk of sexual health disorders and reduced physical fitness correlates with a testosterone concentration of <12 nmol/L. Such patients may require testosterone replacement therapy. We conducted a target literature review to investigate whether testosterone concentration is taken into account in studies on the use of LESWT in the treatment of ED. We found that most studies did not provide any information on testosterone status. Only 8 of 25 studies examined showed values of testosterone concentrations. Only one of these analyses checked the relationship between the efficacy of LESWT and testosterone concentration. As a result, meta-analyses published to date may not show the full value of LESWT in the treatment of ED. We conclude that in the light of the significant role testosterone plays in the process of an erection and the mechanism of LESWT action, it can be recommended to examine testosterone concentration and to diagnose hypogonadism during the qualification of patients to studies on LESWT efficacy. Moreover, the effectiveness of LESWT in relation to the current testosterone concentration should also be further investigated. AME Publishing Company 2020-12 /pmc/articles/PMC7807342/ /pubmed/33457250 http://dx.doi.org/10.21037/tau-20-796 Text en 2020 Translational Andrology and Urology. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Review Article Kałka, Dariusz Biernikiewicz, Małgorzata Gebala, Jana Sobieszczańska, Małgorzata Jakima, Sławomir Pilecki, Witold Rusiecki, Lesław Diagnosis of hypogonadism in patients treated with low energy shock wave therapy for erectile dysfunction: a narrative review |
title | Diagnosis of hypogonadism in patients treated with low energy shock wave therapy for erectile dysfunction: a narrative review |
title_full | Diagnosis of hypogonadism in patients treated with low energy shock wave therapy for erectile dysfunction: a narrative review |
title_fullStr | Diagnosis of hypogonadism in patients treated with low energy shock wave therapy for erectile dysfunction: a narrative review |
title_full_unstemmed | Diagnosis of hypogonadism in patients treated with low energy shock wave therapy for erectile dysfunction: a narrative review |
title_short | Diagnosis of hypogonadism in patients treated with low energy shock wave therapy for erectile dysfunction: a narrative review |
title_sort | diagnosis of hypogonadism in patients treated with low energy shock wave therapy for erectile dysfunction: a narrative review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807342/ https://www.ncbi.nlm.nih.gov/pubmed/33457250 http://dx.doi.org/10.21037/tau-20-796 |
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