Novel bifunctional hybrid compounds designed to enhance the effects of opioids and antagonize the pronociceptive effects of nonopioid peptides as potent analgesics in a rat model of neuropathic pain

The purpose of our work was to determine the role of nonopioid peptides derived from opioid prohormones in sensory hypersensitivity characteristics of neuropathic pain and to propose a pharmacological approach to restore the balance of these endogenous opioid systems. Nonopioid peptides may have a p...

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Detalles Bibliográficos
Autores principales: Piotrowska, Anna, Starnowska-Sokół, Joanna, Makuch, Wioletta, Mika, Joanna, Witkowska, Ewa, Tymecka, Dagmara, Ignaczak, Angelika, Wilenska, Beata, Misicka, Aleksandra, Przewłocka, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808367/
https://www.ncbi.nlm.nih.gov/pubmed/32826750
http://dx.doi.org/10.1097/j.pain.0000000000002045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808367/
https://www.ncbi.nlm.nih.gov/pubmed/32826750
http://dx.doi.org/10.1097/j.pain.0000000000002045

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