Cargando…

Novel bifunctional hybrid compounds designed to enhance the effects of opioids and antagonize the pronociceptive effects of nonopioid peptides as potent analgesics in a rat model of neuropathic pain

The purpose of our work was to determine the role of nonopioid peptides derived from opioid prohormones in sensory hypersensitivity characteristics of neuropathic pain and to propose a pharmacological approach to restore the balance of these endogenous opioid systems. Nonopioid peptides may have a p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Piotrowska, Anna, Starnowska-Sokół, Joanna, Makuch, Wioletta, Mika, Joanna, Witkowska, Ewa, Tymecka, Dagmara, Ignaczak, Angelika, Wilenska, Beata, Misicka, Aleksandra, Przewłocka, Barbara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808367/ https://www.ncbi.nlm.nih.gov/pubmed/32826750 http://dx.doi.org/10.1097/j.pain.0000000000002045

Ejemplares similares

Bifunctional Opioid/Melanocortin Peptidomimetics for Use in Neuropathic Pain: Variation in the Type and Length of the Linker Connecting the Two Pharmacophores
por: Witkowska, Ewa, et al.
Publicado: (2022)

Blockade of P2X4 Receptors Inhibits Neuropathic Pain-Related Behavior by Preventing MMP-9 Activation and, Consequently, Pronociceptive Interleukin Release in a Rat Model
por: Jurga, Agnieszka M., et al.
Publicado: (2017)

Multifunctional Opioid-Derived Hybrids in Neuropathic Pain: Preclinical Evidence, Ideas and Challenges
por: Starnowska-Sokół, Joanna, et al.
Publicado: (2020)

Neuropathic Pain Dysregulates Gene Expression of the Forebrain Opioid and Dopamine Systems
por: Wawrzczak-Bargieła, Agnieszka, et al.
Publicado: (2020)

The RS504393 Influences the Level of Nociceptive Factors and Enhances Opioid Analgesic Potency in Neuropathic Rats
por: Kwiatkowski, Klaudia, et al.
Publicado: (2017)

Mirogabalin Decreases Pain-like Behaviors by Inhibiting the Microglial/Macrophage Activation, p38MAPK Signaling, and Pronociceptive CCL2 and CCL5 Release in a Mouse Model of Neuropathic Pain
por: Zajączkowska, Renata, et al.
Publicado: (2023)

Blockade of Toll-Like Receptors (TLR2, TLR4) Attenuates Pain and Potentiates Buprenorphine Analgesia in a Rat Neuropathic Pain Model
por: Jurga, Agnieszka M., et al.
Publicado: (2016)

Minocycline Enhances the Effectiveness of Nociceptin/Orphanin FQ during Neuropathic Pain
por: Popiolek-Barczyk, Katarzyna, et al.
Publicado: (2014)

Delta-Opioid Receptor Analgesia Is Independent of Microglial Activation in a Rat Model of Neuropathic Pain
por: Mika, Joanna, et al.
Publicado: (2014)

National consumption of opioid and nonopioid analgesics in Croatia: 2007–2013
por: Krnic, Darko, et al.
Publicado: (2015)

Nonopioid Analgesics for Managing Postoperative Pain after Cardiothoracic Surgeries
por: Nair, Abhijit S
Publicado: (2019)

Synthesis, Physicochemical and Biological Study of Gallium-68- and Lutetium-177-Labeled VEGF-A(165)/NRP-1 Complex Inhibitors Based on Peptide A7R and Branched Peptidomimetic
por: Masłowska, Katarzyna, et al.
Publicado: (2022)

Blockade of CC Chemokine Receptor Type 3 Diminishes Pain and Enhances Opioid Analgesic Potency in a Model of Neuropathic Pain
por: Pawlik, Katarzyna, et al.
Publicado: (2021)

Cancer Pain Management: Comprehensive Assessment and Nonopioid Analgesics, Part 1
por: Wickham, Rita J.
Publicado: (2017)

Cross-Cultural Comparison of Nonopioid and Multimodal Analgesic Prescribing in Orthopaedic Trauma
por: Young, Jason D., et al.
Publicado: (2020)

Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease‐activated receptor‐2
por: Lieu, T, et al.
Publicado: (2016)

Full Inhibition of Spinal FAAH Leads to TRPV1-Mediated Analgesic Effects in Neuropathic Rats and Possible Lipoxygenase-Mediated Remodeling of Anandamide Metabolism
por: Starowicz, Katarzyna, et al.
Publicado: (2013)

Pharmacological Inhibition of Indoleamine 2,3-Dioxygenase-2 and Kynurenine 3-Monooxygenase, Enzymes of the Kynurenine Pathway, Significantly Diminishes Neuropathic Pain in a Rat Model
por: Rojewska, Ewelina, et al.
Publicado: (2018)

Dataset of (±)-NBI-74330 (CXCR3 antagonist) influence on chemokines under neuropathic pain
por: Piotrowska, Anna, et al.
Publicado: (2018)

Discharge prescription patterns of opioid and nonopioid analgesics after common surgical procedures
por: Nooromid, Michael J., et al.
Publicado: (2018)

Triazolopeptides Inhibiting the Interaction between Neuropilin-1 and Vascular Endothelial Growth Factor-165
por: Fedorczyk, Bartlomiej, et al.
Publicado: (2019)

PD98059 Influences Immune Factors and Enhances Opioid Analgesia in Model of Neuropathy
por: Rojewska, Ewelina, et al.
Publicado: (2015)

Nonopioid analgesics for perioperative and cardiac surgery pain in children: Current evidence and knowledge gaps
por: Saini, Ashish, et al.
Publicado: (2020)

Nonopioid analgesics discovery and the Valley of Death: EMA401 from concept to clinical trial
por: Smith, Maree T.
Publicado: (2022)

Risk of asthma exacerbation associated with opioid and nonopioid analgesic use in children with current asthma
por: Nair, Abhishek A, et al.
Publicado: (2022)

Metamizole relieves pain by influencing cytokine levels in dorsal root ganglia in a rat model of neuropathic pain
por: Zajaczkowska, Renata, et al.
Publicado: (2020)

Brain Distribution and Metabolism of Flupirtine, a Nonopioid Analgesic Drug with Antiseizure Effects, in Neonatal Rats
por: Patil, Madhoosudan A., et al.
Publicado: (2018)

β(2)-Homo-Amino Acid Scan of µ-Selective Opioid Tetrapeptide TAPP
por: Tymecka, Dagmara, et al.
Publicado: (2020)

Scandium-44 Radiolabeled Peptide and Peptidomimetic Conjugates Targeting Neuropilin-1 Co-Receptor as Potential Tools for Cancer Diagnosis and Anti-Angiogenic Therapy
por: Masłowska, Katarzyna, et al.
Publicado: (2023)

Multifunctional Enkephalin Analogs with a New Biological Profile: MOR/DOR Agonism and KOR Antagonism
por: Lee, Yeon Sun, et al.
Publicado: (2021)

The Role of VEGF Receptors as Molecular Target in Nuclear Medicine for Cancer Diagnosis and Combination Therapy
por: Masłowska, Katarzyna, et al.
Publicado: (2021)

Pharmacological Blockade of Spinal CXCL3/CXCR2 Signaling by NVP CXCR2 20, a Selective CXCR2 Antagonist, Reduces Neuropathic Pain Following Peripheral Nerve Injury
por: Piotrowska, Anna, et al.
Publicado: (2019)

Remifentanil-induced pronociceptive effect and its prevention with pregabalin
por: Jo, Hyong Rae, et al.
Publicado: (2011)

Intrinsic attention to pain is associated with a pronociceptive phenotype
por: Adams, Greig, et al.
Publicado: (2021)

Elevated serotonin in mouse spinal dorsal horn is pronociceptive
por: Cramer, Nathan, et al.
Publicado: (2023)

Biphalin, a Dimeric Enkephalin, Alleviates LPS-Induced Activation in Rat Primary Microglial Cultures in Opioid Receptor-Dependent and Receptor-Independent Manners
por: Popiolek-Barczyk, Katarzyna, et al.
Publicado: (2017)

Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy of Nonopioid Analgesics on Pain following Arthroscopic Knee Surgery
por: Abdulla, Susanne, et al.
Publicado: (2012)

Minimally Invasive Versus Open Transforaminal Lumbar Interbody Fusion Surgery: An Analysis of Opioids, Nonopioid Analgesics, and Perioperative Characteristics
por: Hockley, Aaron, et al.
Publicado: (2019)

Dataset of botulinum toxin A influence on interleukins under neuropathy
por: Zychowska, Magdalena, et al.
Publicado: (2016)

Comparison of the Separation Performances of Cinchona Alkaloid-Based Zwitterionic Stationary Phases in the Enantioseparation of β(2)- and β(3)-Amino Acids
por: Ilisz, István, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_ob1jutheu3n6g62ugff4uhgqd7