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A “Build and Retrieve” methodology to simultaneously solve cryo-EM structures of membrane proteins

Single-particle cryo-electron microscopy (cryo-EM) has become a powerful technique in the field of structural biology. However, the inability to reliably produce pure, homogeneous membrane protein samples significantly hampers the progress of their structural determination. Here, we develop a bottom...

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Detalles Bibliográficos
Autores principales: Su, Chih-Chia, Lyu, Meinan, Morgan, Christopher E., Bolla, Jani Reddy, Robinson, Carol V., Yu, Edward W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808410/
https://www.ncbi.nlm.nih.gov/pubmed/33408407
http://dx.doi.org/10.1038/s41592-020-01021-2