Comparison of quinazoline and benzoylpyrazoline chemotypes targeting the CaVα-β interaction as antagonists of the N-type CaV2.2 channel

Structural studies with an α subunit fragment of voltage-gated calcium (CaV) channels in complex with the CaVβ subunits revealed a high homology between the various CaVα-β subunits, predicting that targeting of this interface would result in nonselective compounds. Despite this likelihood, my labora...

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Detalles Bibliográficos
Autores principales: Ran, Dongzhi, Gomez, Kimberly, Moutal, Aubin, Patek, Marcel, Perez-Miller, Samantha, Khanna, Rajesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808423/
https://www.ncbi.nlm.nih.gov/pubmed/33416017
http://dx.doi.org/10.1080/19336950.2020.1863595

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808423/
https://www.ncbi.nlm.nih.gov/pubmed/33416017
http://dx.doi.org/10.1080/19336950.2020.1863595

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