UV-exposure, endogenous DNA damage, and DNA replication errors shape the spectra of genome changes in human skin
Human skin is continuously exposed to environmental DNA damage leading to the accumulation of somatic mutations over the lifetime of an individual. Mutagenesis in human skin cells can be also caused by endogenous DNA damage and by DNA replication errors. The contributions of these processes to the s...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808690/ https://www.ncbi.nlm.nih.gov/pubmed/33444353 http://dx.doi.org/10.1371/journal.pgen.1009302 |