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UV-exposure, endogenous DNA damage, and DNA replication errors shape the spectra of genome changes in human skin

Human skin is continuously exposed to environmental DNA damage leading to the accumulation of somatic mutations over the lifetime of an individual. Mutagenesis in human skin cells can be also caused by endogenous DNA damage and by DNA replication errors. The contributions of these processes to the s...

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Detalles Bibliográficos
Autores principales:	Saini, Natalie, Giacobone, Camille K., Klimczak, Leszek J., Papas, Brian N., Burkholder, Adam B., Li, Jian-Liang, Fargo, David C., Bai, Re, Gerrish, Kevin, Innes, Cynthia L., Schurman, Shepherd H., Gordenin, Dmitry A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808690/ https://www.ncbi.nlm.nih.gov/pubmed/33444353 http://dx.doi.org/10.1371/journal.pgen.1009302

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